A cross-sectional study correlating serum calcium levels and the state of control of Type 2 Diabetes Mellitus
Abstract
Background:
Calcium plays a major role in secreting insulin in our body other than its various other function, the correlation of calcium and Type 2 Diabetes mellitus is a concept that needed much more justification and evident scientific proofs. This research aimed to study the association of serum calcium levels with Type 2 Diabetes Mellitus.
Methodology:
A total of 351 patients were included in this study which included both newly diagnosed cases of Type 2 Diabetes Mellitus and already known cases of Type 2 Diabetes Mellitus. The study parameters- Fasting blood glucose, post-prandial blood glucose, HbA1C score and Serum Calcium Levels were analysed.
Results:
The Fasting blood glucose levels and post-prandial blood glucose levels of known cases of Type 2 Diabetes Mellitus were 160.89 ± 22.60 mg/dL and 194.33 ± 22.70 mg/dL and that of newly diagnosed cases were 137.90 ± 4.21 mg/dL and 171.48 ± 4.59 mg/dL respectively. The HbA1C score in newly diagnosed cases was 7.20 ± 0.30 and that of known case was 8.90 ± 1.04. The Serum Calcium levels of the newly diagnosed cases was 8.87 ± 0.26 mg/dL and 7.36 ± 0.64 mg/dL for the already known cases.
Conclusion:
Changes in serum calcium levels are associated with the risk of T2DM in an Indian population. Thereby the patients with T2DM have to be supplemented with calcium which would help in progression of the disease furthermore.
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References
2. Seshasai SR, Kaptoge S, Thompson A, et al. (2011) Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 364, 829–841. [PubMed: 21366474]
3. Rooney MR, Pankow JS, Sibley SD, et al. (2016) Serum calcium and incident type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study. Am J Clin Nutr 104, 1023–1029. [PubMed:27510541]
4. Becerra-Tomás N, Estruch R, Bulló M, et al. (2014) Increased serum calcium levels and risk of type 2 diabetes in individuals at high cardiovascular risk. Diabetes Care 37, 3084–3091. [PubMed:25139884]
5. Sorva A & Tilvis RS (1990) Low serum ionized to total calcium ratio: association with geriatric diabetes mellitus and with other cardiovascular risk factors. Gerontology 36, 212–216. [PubMed: 2272524]
6. Peacock M (2010) Calcium metabolism in health and disease. Clin J Am Soc Nephrol 5, S23–S30. [PubMed: 20089499]
7. Sing CW, Cheng VK, Ho DK, et al. (2016) Serum calcium and incident diabetes: an observational study and meta-analysis. Osteoporos Int 27, 1747–1754. [PubMed: 26659066]
8. Zaccardi F, Webb DR, Carter P, et al. (2015) Association between direct measurement of active serum calcium and risk of type 2 diabetes mellitus: a prospective study. Nutr Metab CardiovascDis 25, 562–568. [PubMed: 25933474]
9. Mears D (2004) Regulation of insulin secretion in islets of Langerhans by Ca(2+) channels. J Membr Biol 200, 57–66. [PubMed: 15520904]
10. Wollheim CB & Sharp GW (1981) Regulation of insulin release by calcium. Physiol Rev 61, 914–973. [PubMed: 6117094]
11. American Diabetes Association (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33, S62–S69. [PubMed: 20042775]
12. Procopio M, Magro G, Cesario F, et al. (2002) The oral glucose tolerance test reveals a high frequency of both impaired glucose tolerance and undiagnosed type 2 diabetes mellitus in primary hyperparathyroidism. Diabet Med 19, 958–961. [PubMed: 12421435]
13. UNGER, R. H., R. E. DOBBS, AND L. ORCI. Insulin, glucagon, and somatostatin secretion in the regulation of metabolism. Annu. Rev. Physiol. 40: 307-343, 1978.
14. RASMUSSEN, H., AND D. B. P. GOODMAN. Relationships between calcium and cyclic nucleotides in cell activation. Physiol. Rev. 57: 421-509, 1977.
15. SCARPA, A., AND E. CARAFOLI (Editors). Calcium transport and itell function. Ann. NY Acad. Sci. 307: l-655, 1978.
16. R. P. RUBIN. The role of calcium in the secondary response of the adrenal medulla to acetylcholine. J. Physiol. London 159: 40-57, 1961.
17. BUTCHER, F. Regulation of exocytosis. In: Biochemical Actions of Hormones, edited by G. Litwack. London: Academic, 1978, vol. V, p. 53-99. 59. CAPITO, K., AND C. J. HEDESKOV. T
18. DOUGLAS, W. W. Stimulus-secretion coupling the concept and clues from chromaf6n and other cells. Br. J. Pharmacol. 34: 451-474, 1968.
19. DOUGLAS, W. W. Involvement of calcium in exocytosis and the exocytosis-vesiculation sequence. Biochem. Sot. Symp. 39: l-28, 1974.
20. BERRIDGE, M. J. The interaction of cyclic nucleotides and calcium in the control of cellular activity. Adv. Cyclic Nucleotide Res. 6: l-98, 1975.
21. ASHCROFT, S. J. H. Glucoreceptor mechanisms and the control of insulin release and biosynthesis. Diabetologia 18: 5-15, 1980.
22. HEDESKOV, C. J. Mechanism of glucose-induced insulin secretion. Physiol. Rev. 60: 442-509, 1980.
23. LAMBERT, A. E. The regulation of insulin secretion. Rev. Physiol. Biochem. Phurmucol. 75: 98-159, 1976.
24. ORCI, L. A portrait of the pancreatic B-cell. Diabetologia 10: 163-187, 1974.
25. SHARP, G. W. G. The adenylate cyclase-cyclic AMP system in islets of Langerhans and its role in the control of insulin release. Diabetologia 16: 287-296, 1979.
26. Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999;104:787-794.
27. Mears D. Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels. J Membr Biol 2004;200:57-66.
28. Milner RD, Hales CN. The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro. Diabetologia 1967;3:47-49.
29. Khan AH, Pessin JE. Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia 2002;45:1475-1483.
30. Levy J. Abnormal cell calcium homeostasis in type 2 diabetes mellitus: a new look on old disease. Endocrine 1999;10:1-6.
31. Shimodaira M, Niwa T, Nakajima K, Kobayashi M, Hanyu N, Nakayama T. The relationship between serum calcium level and early-phase insulin secretion in normoglycemic and pre-diabetic individuals. Exp Clin Endocrinol Diabetes 2015;123:165-169.
32. Ryder JW, Gilbert M, Zierath JR. Skeletal muscle and insulin sensitivity: pathophysiological alterations. Front Biosci 2001;6:D154-163.
33. Bjornholm M, Zierath JR. Insulin signal transduction in human skeletal muscle: identifying the defects in Type II diabetes. Biochem Soc Trans 2005;33:354-357.
34. Williams PF, Caterson ID, Cooney GJ, Zilkens RR, Turtle JR. High affinity insulin binding and insulin receptor-effector coupling: modulation by Ca2+. Cell Calcium 1990;11:547-556.
35. Ford ES, Ajani UA, McGuire LC, Liu S. Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes care 2005;28:1228-1230.
36. Baird GS. Ionized calcium. Clin Chim Acta 2011;412:696-701.
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